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Flurbiprofen axetil

Flurbiprofen axetil structure

CAS No:
91503-79-6
Formula:
C19H19FO4
Chemical Name:
Flurbiprofen axetil
Synonyms:
[1,1′-Biphenyl]-4-acetic acid,2-fluoro-α-methyl-,1-(acetyloxy)ethyl ester;Flurbiprofen axetil;LFP 83;1-Acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate;Ropiopn;1-Acetoxyethyl 2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanoate
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Pale Yellow Oil

Flurbiprofen axetil is an organic molecular entity.|Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients).

Flurbiprofen axetil Basic Attributes

Molecular Weight：

330.35

Exact Mass：

330.35

EC Number：

1308068-626-2

UNII：

I0OU31PUI5

DSSTox ID：

DTXSID8048600

Characteristics

PSA：

52.6

XLogP3：

4.04850

Density：

1.2±0.1 g/cm3

Boiling Point：

174 °C @ Press: 0.8 Torr

Flash Point：

203.0±22.2 °C

Refractive Index：

1.529

Safety Information

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

1-acetoxyethyl-2-(2-fluoro-4-biphenyl)propionate

Flurbiprofen axetil Use and Manufacturing

Methods of Manufacturing

Flurbiprofen is dissolved in dimethylformamide, potassium carbonate and dichloroethyl acetate are added, and the reaction is stirred at room temperature to obtain flurbiprofen ester.

Uses

An anti-inflammatory used as an analgesic.

Computed Properties

Molecular Weight:330.3
XLogP3:4.9
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:330.12673725
Monoisotopic Mass:330.12673725
Topological Polar Surface Area:52.6
Heavy Atom Count:24
Complexity:433
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 91503-79-6

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