6-Hydroxy-1,2,3,4-tetrahydroquinoline
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6-Hydroxy-1,2,3,4-tetrahydroquinoline
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CAS No:
3373-00-0
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Formula:
C9H11NO
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Chemical Name:
6-Hydroxy-1,2,3,4-tetrahydroquinoline
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Synonyms:
6-Quinolinol,1,2,3,4-tetrahydro-;1,2,3,4-Tetrahydro-6-quinolinol;6-Hydroxy-1,2,3,4-tetrahydroquinoline
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CAS No:
6-Hydroxy-1,2,3,4-tetrahydroquinoline Basic Attributes
149.19
149.19
222-153-4
DTXSID40187405
2933499090
Characteristics
32.3
1.9
Yellow crystal
1.1±0.1 g/cm3
160 °C
337.5°C at 760 mmHg
189.3±15.5 °C
1.582
Safety Information
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
6-Hydroxy-1,2,3,4-tetrahydroquinoline Use and Manufacturing
Compound 26A (3.00 g, 18.38 mmol) was dissolved in 50 ml of dichloromethane, BBr3 (13.81 g, 55.14 mmol)was added at 0 °C, and then stirred at 15 °C for 2 hours. The reaction solution was concentrated and the reaction wasquenched by 5 ml of methanol. Saturated sodium bicarbonate solution (20 ml) was added and stirred for 30 min, thenextracted with 20 ml of ethyl acetate three times. The organic phases were combined and dried over anhydrous sodiumsulfate and concentrated to give a crude product. The crude product was purified by silica gel column chromatography(petroleum ether/ethyl acetate was from 3:1 to 1:1) to give compound 26B (1.95 g, the yield was 71.11percent).1H NMR (400 MHz, DMSO-d6) 8.24 (s, 1H), 6.22-6.35 (m, 3H), 4.93 (br. s., 1H), 3.02-3.10 (m, 2H), 2.57 (t, J = 6.4 Hz, 2H), 1.67-1.80 (m, 2H).
A potential amoebicide.
Computed Properties
Molecular Weight:149.19
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:149.084063974
Monoisotopic Mass:149.084063974
Topological Polar Surface Area:32.3
Heavy Atom Count:11
Complexity:138
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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6-Hydroxy-1,2,3,4-tetrahydroquinoline
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