Sodium cacodylate

159.98

159.948151

204-708-2

OC4237N148

1688

DTXSID3034408

Colorless to light yellow|Crystalline solid

2931900022

40.13000

0.54920

Sodium cacodylate appears as a white crystalline or granular solid with a slight odor. Toxic by ingestion, inhalation, and skin absorption. Used as a herbicide.

>1 at 20 deg C (solid) (est)

200 °C

253.1ºC at 760 mmHg

109.4ºC

H2O: 0.5 M at 20 °C, clear, colorless

Store at RT.

Oral-rat LD50: 2600 mg/kg; Oral-Mouse LD50: 4000 mg/kg

Thermal decomposition of toxic arsenide gas

None

pKa = 6.29

Granules; slight odor; liquefies in its water of hydration at about 60 °C; becomes anhydrous at 120 °C; burns with a bluish flame, emitting a garlic-like odor; pH about 8-9 /Sodium cacodylate trihydrate/|Deliquescent; white, amorphous crystals or powder; loses water at 120 °C /Sodium cacodylate trihydrate/

Soluble in water.

Salts, Basic

SODIUM CACODYLATE gives basic solutions in water. Corrodes common metals, but reaction is not hazardous. (USCG, 1999). Liquefies in its own water of crystallization when heated to 60°C; becomes anhydrous at 120°C [Merck]. Burns with a bluish flame, emitting a garlic-like odor [Merck].

Corrodes common metals, but reaction is not hazardous.

II

6.1(a)

UN 1688 6.1/PG 2

3

23/25-50/53

20/21-28-45-60-61

CH7890000

T,N

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Stable.

P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P321, P330, P391, P403+P233, P405, P501

H301

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|Storage: To convert the gas-cleaning residues obtained during the metallurgical processing of arsenic-containing ores into a portable and less water-soluble form, the metals are precipitated as hydroxides by using an excess of lime water and the arsenic is precipitated as calcium arsenate and calcium arsenite. This "arsenic sludge" is recycled, on the one hand, in order not to lose the valuable metals, and on the other, in order to reduce the problem of arsenic sludge disposal.

... WHEN WATER SOLN OF ARSENICALS ARE IN CONTACT WITH ACTIVE METALS SUCH AS /IRON, ALUMINUM, OR ZINC, HIGHLY TOXIC FUMES OF ARSENIC ARE EMITTED. /ARSENIC CMPD/

Poisoning potential is high when heated to decomposition, or on contact with acids or acid fumes, because it emits highly toxic fumes of arsenic. Avoid water solution in contact with active metals (iron, aluminum, zinc). (EPA, 1998)|Carcinogens, Reactive - 1st degree

|Danger|H301 (96.3%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 54 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)|Rubber gloves, goggles or face shield for eye protection, rubber apron.|Personnel protection: ... Avoid bodily contact with the material. ... Wear appropriate chemical protective clothing.

Not flammable

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical or carbon dioxide. Keep runoff water out of sewers and water sources.

Keep out of reach of children. ... Avoid inhalation of spray mist. Avoid spray drift to desirable plants.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.|Personnel protection: ... Keep upwind. ... Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment.|ELECTRON MICROSCOPISTS SHOULD SEE THAT EXTREME CARE IS EXCERCISED DURING PREPN OF CACODYLATE BUFFERS.

/GUIDE 152: SUBSTANCES - TOXIC (Combustible)/ Fire or Explosion: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.|/GUIDE 152: SUBSTANCES - TOXIC (Combustible)/ Health: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.|/GUIDE 152: SUBSTANCES - TOXIC (Combustible)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas.|/GUIDE 152: SUBSTANCES - TOXIC (Combustible)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible.|For more DOT Emergency Guidelines (Complete) data for SODIUM CACODYLATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Irritating to skin and eyes.

Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Sodium cacodylate is included on this list.|(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Sodium cacodylate is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered for and has a particle size less than 100 microns; or is handled in solution or in molten form; or meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .

moderately toxic

Muscarinic receptorsare altered by sulfhydryl reagents. Arsenic cmpd, which have been used as insecticides, exert their toxic effects by combining with sulfhydryl groups. The action of arsenicals on the muscarinic receptor from invertebrate and vertebrate species (locust and rat) was compared. Disulfide reducing reagents dithiothreitol and British Anti-Lewisite, but not arsenicals, inhibited (3)H quinuclidinyl benzilate binding. However, after disulfide reduction, arsenicals caused a further inhibition of muscarinic binding. The effect of dithiothreitol + arsenicals was largely irreversible. The locust receptors were more sensitive to the action of both disulfide reagents either in the absence or presence of arsenicals than the rat receptors. The sulfhydryl reagent p-chloromercuric benzoate was more effective at inhibiting the locust receptors than the rat receptors, but addition of arsenicals did not cause further inhibition in either the locust or rat receptors. In locust, dithiothreitol + cacodylate and dithiothreitol + arsenite caused a reduction in the number of sites without modifying the affinity of (3)H quinuclidinyl benzilate binding. In rat, dithiothreitol + arsenite caused a decrease in the affinity, while dithiothreitol + cacodylate caused a decrease in the affinity of (3)H quinuclidinyl benzilate binding and its number of sites. Competition experiments after dithiothreitol + cacodylate showed that the IC50 remained unchanged in the locust. In the rat, the IC50 for atropine was increased and increased for carbachol. These results are explained assuming that the binding site of the locust receptor has a disulfide group similar to that of the mammalian receptor, but that th hydrophobic interactions within the binding site are weaker in the locust receptor.

LD50 Rat oral 2600 mg/kg|LD50 Mouse oral 4 mg/kg

ORGANOARSENICALS, SUCH AS DIMETHYLARSINIC ACID ... & SODIUM CACODYLATE ARE ADSORBED BY CLAY SOILS. ... DOWNWARD LEACHING OF METHANEARSONIC ACID SALTS HAS ALSO BEEN REPORTED. THE METHANEARSONIC ACID SALTS & DIMETHYLARSINIC ACID ARE FIXED BY IRON & ALUMINUM IN SOIL, ALTHOUGH NOT AS STRONGLY AS INORGANIC ARSENATE.

MEDICATION (VET): Has been used in chronic eczema, anemia, as a tonic.|MEDICATION (VET): FORMERLY AS IV THERAPY (AS MIXED SODIUM AND IRON CACODYLATES) IN CONVALESCENCE, ANEMIAS, AND SKIN DISEASES OF HORSES, CATTLE AND DOGS. ...OCCASIONALLY USED ORALLY...FOR CATS AND DOGS...

FIVE DOSES OF SODIUM CACODYLATE (194 MG) WERE ADMIN IV TO 2 HORSES AT 2 DAY INTERVALS. URINARY ARSENIC CONTENT WAS DETERMINED FOR 5 DAYS AFTER FINAL DOSE AT WHICH TIME CONCN WERE CLOSE TO CONTROL SAMPLES. ORG ARSENICALS ARE MORE RAPIDLY EXCRETED BY ANIMALS THAN INORG CMPD.

... METAB OF CACODYLIC ACID IN BLACK VALENTINE BEANS /WAS STUDIED/. ANALYSIS OF THE EXTRACT REVEALED AS, PRESUMED TO BE CACODYLIC ACID /CA/, IN THE CHROMATOGRAM WHERE CA SHOULD HAVE BEEN. THE ABSENCE OF AS3+ & MSMA /MONOSODIUM METHANEARSONATE/ WAS DEMONSTRATED. IN SEPARATE EXPT, NO ARSINE ... DETECTED EVEN THOUGH SEVERE TOXICITY DEVELOPED ... . IN CONCLUSION, APPARENTLY NO DEGRADATION OF CACODYLIC ACID OCCURS IN PLANTS BASED ON LIMITED STUDIES. VARIOUS ORGANISMS, HOWEVER, ARE CAPABLE OF REDUCING CACODYLIC ACID TO DI- OR TRIMETHYLARSINE. /CACODYLIC ACID/|METHANOBACTERIUM SPECIES (STRAIN M.OH) IN AN INCUBATION MIXTURE UNDER ANAEROBIC CONDITIONS REDUCED CACODYLIC ACID TO DIMETHYLARSINE IN ABSENCE OF A C-1 DONOR. /CACODYLIC ACID/

When administered to rats, cacodylic acid was rapidly absorbed from the lung with a half-time of 2.2 min. Peroral absorption half-time was 248 min. The half-time for clearance from the whole blood after intravenous, intratracheal and peroral administration as 92, 76 and 90 days, respectively. In pregnant rats, cacodylic acid readily crossed the placenta. The small amount of carbon dioxide evolved indicated that only a small fraction of the dose was demethylated. /Cacodylic acid/

Moderately toxic; probable oral lethal dose in humans is 0.5-5 g/kg or between 1 ounce and 1 pint (or 1 lb.) for a 70 kg (150 lb.) person. It may cause disturbances of the blood, kidneys, and nervous system. (EPA, 1998)

Warning: Effects usually appear within 30 to 60 minutes but may be delayed for several hours. Caution is advised. Signs and Symptoms of Acute Sodium Cacodylate Exposure: Acute exposure to sodium cacodylate may be fatal. Headache, red-stained eyes, and a garlicky odor of the breath may be the first effects noticed. Other signs and symptoms include generalized weakness, intense thirst, muscle cramping, seizures, toxic delirium, and shock. Nausea, vomiting, anorexia, abdominal pain, and diarrhea may occur. Hypotension (low blood pressure), tachycardia (rapid heart rate), pulmonary edema, ventricular fibrillation, and other cardiac abnormalities are usually found following severe exposure. Sodium cacodylate is corrosive to the skin, eyes, and mucous membranes. Emergency Life-Support Procedures: Acute exposure to sodium cacodylate may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to sodium cacodylate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. RUSH to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self- exposure to sodium cacodylate. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 3. Remove contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas for at least 15 minutes with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. RUSH to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. RUSH to a health care facility. (EPA, 1998)

STRONG GARLIC ODOR IS IMPARTED TO BREATH, SWEAT, & URINE.|Ingestion or excessive inhalation causes irritation of stomach and intestines with nausea, vomiting, diarrhea, shock, rapid pulse, coma.|Irritating to skin and eyes.

USEPA/OPP Pesticide Code 012502; Trade Names: Ansar 160; Ansar 560; Bolls-Eye; Chemaid; Phytar 560, component of (with 012501); Rad-E-Cate 25.|PHYTAR 160 CONTAINS 3.25 LB/GAL; RAD-E-CATE 35 CONTAINS 3.25 LB/GAL & SURFACTANT; PHYTAR 560 CONTAINS 2.48 LB/GAL & SURFACTANT; BROADSIDE CONTAINS 3.0 LB/GAL MSMA & 1.25 LB/GAL NA-CACODYLATE; CHEX-MATE CONTAINS 3.00 LB/GAL MSMA, 1.25 LB/GAL NA-CACODYLATE & SURFACTANT. RAD-E-CATE 25 CONTAINS 2.48 LB/GAL & SURFACTANT; BOLLS-EYE CONTAINS 3.10 LB/GAL; PHYTAR 535 CONTAINS 3.25 LB/GAL; PHYTAR 138 CONTAINS 80% SODIUM-CACODYLATE & IS FREE ACID. /FROM TABLE/|SODIUM CACODYLATE IS AVAILABLE FOR FARM APPLICATIONS AS CONCENTRATED SOLN, AS 25% SOLN WITH SURFACTANT, IN COMBINATION WITH DIMETHYLARSINIC ACID OR IN COMBINATION WITH METHANEARSONIC ACID, MONOSODIUM SALT & SURFACTANT.|Bolls-eye; Phytar 560; Rad-E-cate 16; Rad-E-cate 25; Rad-E-cate 35|For more Formulations/Preparations (Complete) data for SODIUM CACODYLATE (6 total), please visit the HSDB record page.

Arsinic acid, As,As-dimethyl-, sodium salt (1:1): ACTIVE|CONTAINS APPROX 35% ARSENIC (47% IN ANHYDROUS FORM).|Grades or purity: 22-28% sodium cacodylate, 3-5% cacodylic acid, balance inert solid (or water).|... The safe parenteral dose (300 mg) is significantly larger than the safe oral dose (60 mg) because acidic gastric juice rapidly frees inorganic arsenic, presumably as arsenic acid, which is then reduced to trivalent arsenous oxide.

AOAC Method 526.16. Arsenic in Sodium Cacodylate. Titrimetric Method.|SODIUM CACODYLATE IN DISTILLED WATER OR SEWAGE SLUDGE WAS ELECTROPHORESED IN 0.05 M SODIUM CITRATE BUFFER AT PH 7 FOR 60 MIN & DEVELOPED WITH (NH4)2 GIVING GOOD COLOR DEFINITION.

Agrochemicals -> Rodenticides|Fire Hazards -> Carcinogens, Reactive - 1st degree|HERBICIDES