Pentobarbital sodium
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Pentobarbital sodium
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CAS No:
57-33-0
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Formula:
C11H18N2O3.Na
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Chemical Name:
Pentobarbital sodium
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Synonyms:
2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-,sodium salt (1:1);Barbituric acid,5-ethyl-5-(1-methylbutyl)-,sodium salt;2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-(1-methylbutyl)-,monosodium salt;844;Barpental;Embutal;Isobarb;Mebubarbital sodium;Napental;Nembutal sodium;Pental;Pentobarbital sodium;Pentobarbitone sodium;Pentone;Sagatal;Sodium ethaminal;Sodium 5-ethyl-5-(1-methylbutyl)barbiturate;Sodium nembutal;Sodium-Pent;Sodium pentobarbital;Sodium pentobarbitone;Sodium pentobarbiturate;Soluble pentobarbital;Sopental;Sotyl;Ethaminal sodium;5-Ethyl-5-(1-methylbutyl) barbituric acid sodium salt;Diabutal;Vetbutal;Mebumal sodium;Pacifan;Etaminal sodium;Pentonal;Auropan;Euthatal;Somnopentyl;Biosedan;Butylone;V-Pento;Mebunat;Euthanyl;RS-Pentobarbital sodium;Praecicalm;Narcoren;Somnotol;NSC 10816;Sodium pental;Entobar;8023-11-8;8050-99-5;10579-81-4;23714-57-0
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CAS No:
Description
A white or almost white, crystalline powder, hygroscopic.
Pentobarbital sodium appears as crystalline granules or white powder. Used as an anesthetic and sedative.
Pentobarbital sodium appears as crystalline granules or white powder. Used as an anesthetic and sedative.
Characteristics
81.6
Pentobarbital sodium appears as crystalline granules or white powder. Used as an anesthetic and sedative.
127 °C (decomp)
H2O: soluble
LD50 orally in rats: 118 mg/kg (Schafer)
Freely soluble in water. Aqueous solutions are unstable upon storage.
Amides and Imides
Safety Information
6.1(b)
UN 2811 6.1/PG 3
3
25
45
CQ6125000
T
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016)
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P273, P281, P301+P310, P307+P311, P308+P313, P321, P330, P405, and P501|Aggregated GHS information provided by 76 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)
Drug Information
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)
Computed Properties
Molecular Weight:248.25
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:248.11368669
Monoisotopic Mass:248.11368669
Topological Polar Surface Area:64.2
Heavy Atom Count:17
Complexity:333
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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