BRADYKININ
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BRADYKININ
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CAS No:
58-82-2
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Formula:
C50H73N15O11
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Chemical Name:
BRADYKININ
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Synonyms:
bk;brs640;prs640;C00306;RPPGFSPFR;BRADYZIDE;Callideic;KallidinⅠ;BRADYKININ;CallidinI
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CAS No:
Description
Bradykinin is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions.
Solid
Bradykinin is a linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation. It has a role as a human blood serum metabolite and a vasodilator agent. It is a tautomer of a bradykinin(2+).|Bradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2.|Bradykinin is bradykinin (9 aa, ~1 kDa) is encoded by the human KNG1 gene. This protein is involved in blood pressure regulation and pain receptor stimulation.|A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.
Characteristics
419
-0.82
Solid
1.5±0.1 g/cm3
170ºC
1.693
soluble to 1 mg/ml in water.
−20°C
Abdominal-rat TDL0: 0.00053 mg/kg; intravenous-rat TDL0: 0.000212 mg/kg
Thermal decomposition to release toxic nitrogen oxide gas
D25 -76.5° (c = 1.37 in 1N acetic acid)
343.33 Ų [M+2H]2+ [CCS Type: DT, Method: stepped-field]|447.61 Ų [M+3H]3+ [CCS Type: DT, Method: stepped-field]|315.25 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|344.2 Ų [M+2H]2+
Safety Information
3
22-24/25
EE1530000
The warehouse is ventilated, low temperature, dry, closed, and stored separately from food materials
Drug Information
Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)
Arg Pro Pro Gly Phe Ser Pro Phe Arg
Computed Properties
Molecular Weight:1060.2
XLogP3:-4.8
Hydrogen Bond Donor Count:12
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:27
Exact Mass:1059.56139820
Monoisotopic Mass:1059.56139820
Topological Polar Surface Area:419
Heavy Atom Count:76
Complexity:2080
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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