Cupric acetate

123.59800

122.95100

224-051-5

39M11XPH03

3077

DTXSID2059720

Blue-green hydroscopic powder

37.30000

0.08840

Cupric acetate appears as a blue-green crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used as an insecticide, in the preparation of other chemicals, as a fungicide, and mildew preventive.

1.068g/cm3

232 °C

117.1ºC at 760 mmHg

40ºC

INDEX OF REFRACTION: 1.545, 1.550; SOL 7.2 G/100 CC COLD WATER; 20 G/100 CC HOT WATER /MONOHYDRATE/

Dark green, monoclinic crystals; exists in dimeric units; mp: 115 °C; decomp @ 240 °C; density: 1.882. Sol in water, alcohol; slightly sol in ether, glycerol. /Monohydrate/|Efflorescent /Monohydrate/|Odorless /Monohydrate/

Water soluble.

Salts, Basic

Salts, basic, such as CUPRIC ACETATE, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

UN 3077

3

R22;R36/37/38;R50/53

S26-S60-S61

AG3480000

Xn:Harmful;N:Dangerousfortheenvironment;

P260-P280-P301 + P312 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

H302-H314-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

NAS; Medical and Biologic Effects of Environmental Pollutants Copper (1974)|USEPA; Ambient Water Quality Criteria Doc: Copper (1980) EPA 440/5-80-036.|USEPA; Health Issue Assessment: Copper (1987) EPA/600/8-87/001.|USEPA; Drinking Water Criteria Document for Copper (Final Draft) (1985) EPA-600/X-84-190-1|USEPA; Ambient Water Quality Criteria Doc: Copper (1984) EPA 440/5-84-031.

Special Hazards of Combustion Products: Irritating vapors of acetic acid may form in fires. (USCG, 1999)

|Danger|H301 (24.74%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P273, P280, P301+P310, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P361, P363, P391, P405, and P501|Aggregated GHS information provided by 561 companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 170 companies from 1 notifications to the ECHA C&L Inventory.|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P301+P312, P304+P340, P307+P311, P312, P314, P321, P330, P403+P233, P405, and P501

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: SMALL FIRE: Dry chemical, CO2, water spray or regular foam. LARGE FIRE: Water spray, fog or regular foam. Do not scatter spilled material with high-pressure water streams. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal. FIRE INVOLVING TANKS: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. Avoid inhalation of asbestos dust. SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area. SMALL SPILL: Pick up with sand or other non-combustible absorbent material and place into containers for later disposal. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2016)

Dust mask; goggles or face shield; protective gloves (USCG, 1999)|Personnel protection: ... Wear appropriate chemical protective gloves, boots and goggles.

It is noncombustible.

Environmental consideration - land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.|Environmental consideration - water spill: Neutralize with agricultural lime (calcium oxide), crushed limestone (calcium carbonate), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH= 7). Use mechanical dredges or lifts to remove immobilized masses of pollutants & precipitates.

If material not involved in fire: Keep material out of water sources & sewers. Build dikes to contain flow as necessary.|Personnel protection: Keep upwind. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amt of water or soap & water.|SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.|SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Inhalation of dust causes irritation of throat & lung. ... Contact with solutions irritates eyes; contact with solid causes severe eye surface injury & irritation of skin. /Copper acetate monohydrate/

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1 mg/cu m. /Copper dusts and mists (as Cu)/

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Copper (dusts and mists)/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

The effect of cupric acetate on dimethylnitrosamine induced hepatocarcinogenesis in rats was investigated. The surviving rats in the group given dimethylnitrosamine (25 ppm) in the drinking water alone were killed at 26 wk and it was found that 12 of 16 rats had developed liver tumors. In the group given dimethylnitrosamine and cupric acetate (sc injections of 2 copper/kg once a week for 26 wk), 7 of 22 rats developed liver tumors. The incidence of liver tumors in rats given dimethylnitrosamine and cupric acetate was thus only about 40% of that in rats given dimethylnitrosamine alone. No tumor was observed in the group given saline or cupric acetate alone. The thymidine incorporation into the liver DNA of rats given dimethylnitrosamine was significantly suppressed by the administration of cupric acetate. The methylation of liver DNA in rats given a single dose of dimethylnitrosamine was also significantly suppressed by sc injection of cupric acetate; the formation of both O6-methylguanine and 7-methylguanine was reduced. This result suggests that sc injection of cupric acetate may have a suppressive effect on the initiation of carcinogenesis in the liver.|Hepatic lesions by D-L-ethionine in rats produce a significant increase in the blood serum xanthine dehydrogenase activity. Cupric acetate is a potent inhibitor (Ki = 3.42 X 10(-6) M) of the xanthine dehydrogenase activity. Ethionine protects against the inhibitory effect of cupric acetate by formation of a copper complex with behaviour different from that of free ethionine.|The effects of copper acetate and aflatoxin dietary supplements on serum vitamins A and E, albumin, cholesterol and the formed elements of blood in male rats were investigated. CuAc and aflatoxin dietary supplements were 0.5% and 7.8 ppm, respectively. Vitamins A and E, red blood cell count (RBC), mean cell volume (MCV), mean cell Hb content (MCHC) and hematocrit (Hct) were not significantly altered by either supplement while albumin and cholesterol was significantly elevated in groups receiving CuAc or aflatoxin. Serum Hb (HBG) was depressed in animals receiving aflatoxin + CuAc supplement while the WBC (white blood cell) count was depressed in both groups receiving CuAc while aflatoxin had no effect.

LD50 Rat Oral 595 mg/kg body weight [equivalent copper dose: 208 mg Cu/kg body weight /from table/

Medication (VET): In hematinic mixtures (liquid or tablets) as source of copper.

There are limited data concerning toxicity of copper in experimental animals. Heavy accumulation of copper was observed in the liver and kidneys of rats maintained for 16 mo on a diet supplemented with 5,000 ppm copper acetate. Similar depositions were seen in the liver and kidney as well as the brain and the large and small bowel in rats exposed to 1250 ppm cupric acetate monohydrate in the drinking water for up to 902 days.

The effects of cadmium and copper on the sodium ion (Na(+)) glucose cotransport in the kidney cortical cells of 4 week old male C57B16-rats were studied. Different concentrations of cadmium chloride, zinc chloride, or cupric acetate were added to the culture media. The Na(+)-glucose cotransport was estimated from the uptake of radiolabeled alpha-methylglucoside using scintillation counting techniques. Metallothionein was measured by Sephadex-G-75 column chromatography and subsequent high performance liquid chromatography. For Cd(2+) and Cu(2+), an increase in concentration resulted in an increase in the extent of inhibition of the Na(+)-glucose cotransport with approximately 3 hour lag times for the induction of inhibition. Increases in metal ion concentration also resulted in slower increases of metallothionein protein, with the rapid induction of metallothionein messenger RNA after incubation with the ions. Pretreatment of the cells with zinc(2+) reduced the effects of Cd(2+) and Cu(2+) on the cotransport by delaying the onset and reducing the extent of the inhibition.|Ascorbic acid incubation reduced the occurrence of copper acetate induced increases in methemoglobin, while not effecting changes in glutathione in rats.

Inhalation of dust causes irritation of throat and lungs. Ingestion of large amounts causes violent vomiting and purging, intense pain, collapse, coma, convulsions, and paralysis. Contact with solutions irritates eyes; contact with solid causes severe eye surface injury and irritation of skin. (USCG, 1999)

INHALATION: move to fresh air. INGESTION: give large amount of water; induce vomiting; get medical attention. EYES: flush with water for at least 15 min.; get medical attention if injury was caused by solid. SKIN: flush with water. (USCG, 1999)

copper(I) acetate

Grades or purity: technical, 95-99%; reagent, 99%

Laboratory Use|Acetic acid, copper(2+) salt (2:1): ACTIVE|First factory-made basic copper fungicide introduced in 1889|Cupric acetate and cupric nitrate, showed excellent preservation of mosses and lichens, and very good preservation of ferns and grasses.

Cosmetics -> Skin conditioning