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Vecuronium

Vecuronium structure

CAS No:
50700-72-6
Formula:
C34H57N2O4.Br
Chemical Name:
Vecuronium
Synonyms:
Piperidinium,1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-,bromide (1:1);Piperidinium,1-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-,bromide;Androstane,piperidinium deriv.;Org-NC 45;NC 45;Vecuronium bromide;Norcuron;Vecuronium;Musculax;63884-29-7;72254-12-7;74531-67-2
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

Vecuronium bromide is a nondepolarizing neuromuscular blocking agent of intermediate duration.

Vecuronium bromide is the organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium substituents. It has a role as a nicotinic antagonist, a neuromuscular agent and a muscle relaxant. It is a quaternary ammonium salt and an organic bromide salt. It contains a vecuronium. It derives from a 5alpha-androstane.|Vecuronium Bromide is the bromide salt form of vecuronium, a synthetic steroid derivative of the naturally occurring alkaloids of curare with a muscle relaxant property. Vecuronium bromide competes with acetylcholine for the nicotinic receptors at the neuromuscular junction of skeletal muscles, thereby inhibiting the action of acetylcholine and blocking the neural transmission without depolarizing the postsynaptic membrane. This leads to skeletal muscle relaxation and paralysis.|Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents.

Vecuronium Basic Attributes

Molecular Weight：

637.73138

Exact Mass：

636.350159

EC Number：

256-723-9

UNII：

7E4PHP5N1D

DSSTox ID：

DTXSID1023736

NCI Thesaurus Code：

C47782

HScode：

2933399090

Characteristics

PSA：

55.8

XLogP3：

2.86660

Appearance：

white powder

Melting Point：

228 °C

Storage Conditions：

Store in original container in a cool dark place.

Toxicity：

LD50 in mice: 0.061 mg/kg i.v. (Buckett)

Collision Cross Section：

248.4 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

26-37/39

Marks：

Xi: Irritant;

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (98.28%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P271, P280, P284, P301+P312, P302+P352, P304+P340, P310, P312, P320, P322, P330, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 58 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)|Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses. (See all compounds classified as Nicotinic Antagonists.)

MeSH Entry Terms：

Bromide, Vecuronium

Vecuronium Use and Manufacturing

Uses

An aminosteroid, competitive neuromuscular blocker agent.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:637.7
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:636.35017
Monoisotopic Mass:636.35017
Topological Polar Surface Area:55.8
Heavy Atom Count:41
Complexity:958
Defined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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