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Rimonabant hydrochloride

Rimonabant hydrochloride structure

CAS No:
158681-13-1
Formula:
C22H21Cl3N4O.ClH
Chemical Name:
Rimonabant hydrochloride
Synonyms:
1H-Pyrazole-3-carboxamide,5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-,hydrochloride (1:1);1H-Pyrazole-3-carboxamide,5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-,monohydrochloride;SR 141716A;Rimonabant hydrochloride;SR 151716A;5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide hydrochloride;Ribafit;Riomont;Slimbant
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

White to Off-White Crystalline Solid

A pyrazole and piperidine derivative that acts as a selective cannabinoid type-1 receptor (CB1 RECEPTOR) antagonist. It inhibits the proliferation and maturation of ADIPOCYTES, improves lipid and glucose metabolism, and regulates food intake and energy balance. It is used in the management of OBESITY.

Rimonabant hydrochloride Basic Attributes

Molecular Weight：

500.245

Exact Mass：

498.054779

UNII：

HL0V2LQZ09

DSSTox ID：

DTXSID20166495

Characteristics

PSA：

50.2

XLogP3：

7.06940

Appearance：

Off-white to white crystalline powder

Melting Point：

230-240°C

Boiling Point：

627.6ºC at 760 mmHg

Flash Point：

333.3ºC

Water Solubility：

DMSO: soluble 20mg/mL, clear

Safety Information

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

25-36

safety instructions：

26-45

Marks：

T,Xi

Precautionary statement(s)：

P301 + P310-P305 + P351 + P338

Hazard Statements：

H301-H319

Drug Information

MeSH：

Agents that increase energy expenditure and weight loss by neural and metabolic regulation. (See all compounds classified as Anti-Obesity Agents.)|Compounds that inhibit or block the activity of CANNABINOID RECEPTORS. (See all compounds classified as Cannabinoid Receptor Antagonists.)

MeSH Entry Terms：

acomplia

Rimonabant hydrochloride Use and Manufacturing

The first of a new class of selective (Cannabinoid-1 (CB-1) receptor antagonists A brain cannabinoid receptor (CB1) antagonist. Antiobesity agent.

Computed Properties

Molecular Weight:500.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:500.051822
Monoisotopic Mass:498.054772
Topological Polar Surface Area:50.2
Heavy Atom Count:31
Complexity:583
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Thionyl chloride

Diethyl oxalate

Potassium tert-butoxide

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Rimonabant hydrochloride

CAS No.: 158681-13-1

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