6-Amino-2-aza-spiro[3.3]heptane-2-carb...
-
![6-Amino-2-aza-spiro[3.3]heptane-2-carb... structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/4585a1f1ba8740afa8eeab2a581ab568.png "6-Amino-2-aza-spiro[3.3]heptane-2-carb...")
6-Amino-2-aza-spiro[3.3]heptane-2-carb...
structure -
-
CAS No:
1211586-09-2
-
Formula:
C11H20N2O2
-
Chemical Name:
6-Amino-2-aza-spiro[3.3]heptane-2-carb...
- Categories:
-
CAS No:
6-Amino-2-aza-spiro[3.3]heptane-2-carb... Basic Attributes
212.2887
212.15200
1592732-453-0
DTXSID80677370
2933990090
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
6-Amino-2-aza-spiro[3.3]heptane-2-carb... Use and Manufacturing
To a mixture of HATU (99 mg, 0.26 mmol) and 2-(4-chloro-3-fluoro-phenoxy)acetic acid (48 mg, 0.24 mmol) in DMF (5 mL) was added tert-butyl 6-amino-2-azaspiro[3.3jheptane-2-carboxylate (50 mg, 0.24 mmol) and Na2CO3 (50 mg, 0.47 mmol), and the mixture was stirred at 20 C for 16 h. The mixture was poured into ice-water (15 mL) and extracted with EtOAc (3 x 5 mL). The combined organic phases were washed with brine (3 x 5 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by prep-TLC (Si02, PE:EtOAc = 3:1) to provide desired compound. LC-MS mlz: = 343.1, 345.1 [M+H-56j. 'H-NMR (400 MHz, CDC13): oe 7.34 (t, J= 8.6 Hz, 1H), 6.76 (dd, J= 2.8, 10.3 Hz, 1H), 6.67 (td, J = 1.4, 8.9 Hz, 1H), 6.53 (br d, J= 7.4 Hz, 1H), 4.42(s, 2H), 4.40-4.33 (m, 1H), 3.98 (s, 2H), 3.87 (s, 2H), 2.64 (ddd, J=2.9, 7.5, 10.0 Hz, 2H), 2.13 (dt, J= 2.9, 9.3 Hz, 2H), 1.44 (s, 9H)6-Amino-2-Boc-2-azaspiro[3.3]heptane (504 mg, 2.37 mmol), 3, 6-dichloropyridazine (884 mg, 5.93 mmol) and DIPEA (1.24 mL, 7.12 mmol) were dissolved in t-BuOH (3 mL) in a sealed vial, which was heated to 100 C overnight, after which time the reaction mixture was cooled to r.t. and diluted with DCM and sat. NaHCO3. The aqueous layer was extracted with DCM, and the combined organic extracts were filtered through a phase separator and concentrated. The crude residue was purified by column chromatography (hexanes/EtOAc) to give the title compound as a white solid (335 mg, 44%).1H-NMR (400 MHz, CDCl3) 7.17 (d, J = 9.2, 1H), 6.56 (d, J = 9.2, 1H), 4.79 (br, 1H), 4.25- 4.16 (m, 1H), 3.99 (s, 2H), 3.89 (s, 2H), 2.76- 2.71 (m, 2H), 2.10- 2.03 (m, 2H), 1.43 (s, 9H). ES-MS [M+H]+ = 269.4 (minus t-butyl).
Computed Properties
Molecular Weight:212.29
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:212.152477885
Monoisotopic Mass:212.152477885
Topological Polar Surface Area:55.6
Heavy Atom Count:15
Complexity:269
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 6-Amino-2-aza-spiro[3.3]heptane-2-carb...
-
![China]()
CN
4 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food AdditivesInquiryCAS No.: 1211586-09-2Content: 99.00% -
![China]()
CN
1 YR
Business licensed Certified factoryManufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acidInquiryCAS No.: 1211586-09-2Grade: Industrial GradeContent: 95%
Learn More Other Chemicals
-
(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID
51485-76-8
-
Benadryl N-oxide hydrochloride
13168-00-8
-
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE
885275-59-2
-
(2-Bromophenyl)diphenylphosphine Formula
62336-24-7
-
1-Morpholinocyclopentene Formula
936-52-7
-
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula
168892-66-8
-
3-amino-5-bromopyridine-2-carboxylic acid Structure
870997-85-6
-
2-Amino-6-methylpyridine Structure
1824-81-3
-
What is 3-Bromo-2-methylthiophene
30319-05-2
-
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER
2026-42-8
6-Amino-2-aza-spiro[3.3]heptane-2-carb...
SDSRequest for Quotation