2,3-Dichloroaniline Safety Data Sheets

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SAFETY DATA SHEETS

According to the UN GHS revision 8

Version: 1.0

Creation Date: July 15, 2019

Revision Date: July 15, 2019

SECTION 1: Identification

1.1 GHS Product identifier

Product name	2,3-dichloroaniline

1.2 Other means of identification

Product number	-
Other names	Aniline,2,3-dichloro; 2,3-dichloro-anilin; 1-amino-2,3-dichlorobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses	Industrial and scientific research uses.
Uses advised against	no data available

1.4 Supplier's details

Company	Echemi.com
Address	Echemi.com
Telephone	Echemi.com

1.5 Emergency phone number

Emergency phone number	Echemi.com
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

SECTION 2: Hazard identification

2.1 Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Acute toxicity - Category 3, Dermal

Skin irritation, Category 2

Skin sensitization, Category 1

Serious eye damage, Category 1

Acute toxicity - Category 3, Inhalation

Germ cell mutagenicity, Category 2

Carcinogenicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

2.2 GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H311 Toxic in contact with skin H315 Causes skin irritation H317 May cause an allergic skin reaction H318 Causes serious eye damage H331 Toxic if inhaled H341 Suspected of causing genetic defects H350 May cause cancer H372 Causes damage to organs through prolonged or repeated exposure H410 Very toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

2.3 Other hazards which do not result in classification

no data available

SECTION 3: Composition/information on ingredients

3.1 Substances

Chemical name	Common names and synonyms	CAS number	EC number	Concentration
2,3-dichloroaniline	2,3-dichloroaniline	608-27-5	210-157-9	100%

SECTION 4: First-aid measures

4.1 Description of necessary first-aid measures

If inhaled

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Following skin contact

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

Following eye contact

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Following ingestion

Rinse mouth. Give one or two glasses of water to drink. Refer for medical attention .

4.2 Most important symptoms/effects, acute and delayed

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

4.3 Indication of immediate medical attention and special treatment needed, if necessary

Basic treatment: Establish patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Aniline and related compounds

SECTION 5: Fire-fighting measures

5.1 Suitable extinguishing media

If material on fire or involved in fire: Use dry chemical or carbon dioxide. Cool all affected containers with flooding quantities of water. Use water in flooding quantities as fog. Dichloroaniline

5.2 Specific hazards arising from the chemical

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

5.3 Special protective actions for fire-fighters

Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Personal protection: chemical protection suit including self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Collect leaking and spilled liquid in sealable containers as far as possible. Carefully collect remainder. Then store and dispose of according to local regulations.

6.2 Environmental precautions

Personal protection: chemical protection suit including self-contained breathing apparatus. Remove all ignition sources. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. Collect leaking and spilled liquid in sealable containers as far as possible. Carefully collect remainder. Then store and dispose of according to local regulations.

6.3 Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2 Conditions for safe storage, including any incompatibilities

Separated from strong oxidants and food and feedstuffs. Provision to contain effluent from fire extinguishing.STORE IN A COOL, DRY, WELL-VENTILATED LOCATION. SEPARATE FROM ACIDS, OXIDIZING MATERIALS, & COMBUSTIBLES. DICHLOROANILINES

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

8.2 Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3 Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear safety goggles or face shield.

Skin protection

Protective gloves. Protective clothing.

Respiratory protection

Use local exhaust or breathing protection.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties and safety characteristics

Physical state	Solid.
Colour	NEEDLES FROM PETROLEUM ETHER
Odour	no data available
Melting point/freezing point	24 Â°C.
Boiling point or initial boiling point and boiling range	255 Â°C.
Flammability	Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Heating will cause rise in pressure with risk of bursting.
Lower and upper explosion limit/flammability limit	no data available
Flash point	> 112 Â°C.
Auto-ignition temperature	> 500 Â°C.
Decomposition temperature	no data available
pH	no data available
Kinematic viscosity	dynamic viscosity (in mPa s) = 9.53. Temperature:20Â°C.;kinematic viscosity (in mmÂ²/s) = 7.12. Temperature:20Â°C. Remarks:Calculated from dynamic viscosity and density.
Solubility	VERY SOL IN ETHER; SLIGHTLY SOL IN PETROLEUM ETHER, BENZENE
Partition coefficient n-octanol/water	log Pow = 2.78.
Vapour pressure	10.6 mBar. Temperature:112.4 Â°C. Remarks:=10.6 hPa.
Density and/or relative density	1.38.
Relative vapour density	(air = 1): 5.6
Particle characteristics	no data available

SECTION 10: Stability and reactivity

10.1 Reactivity

Decomposes on burning. This produces toxic fumes of nitrogen oxides and hydrogen chloride (see ICSC 0163).

10.2 Chemical stability

no data available

10.3 Possibility of hazardous reactions

A halogenated aromatic amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

10.4 Conditions to avoid

no data available

10.5 Incompatible materials

no data available

10.6 Hazardous decomposition products

When heated to decomposition it emits highly toxic fumes of /hydrogen chloride/ and nitrogen oxides. 2,5-Dichloroaniline

SECTION 11: Toxicological information

Acute toxicity

Oral: LD50 - rat (male) - 2 635 mg/kg bw.
Inhalation: LC50 - rat (male/female) - > 8 047 mg/mÂ³ air.
Dermal: LD50 - rat (male) - >= 934 mg/kg bw.

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Exposure could cause death. The effects may be delayed. Medical observation is indicated.

STOT-repeated exposure

The substance may have effects on the blood. This may result in the formation of methaemoglobin.

Aspiration hazard

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20Â°C.

SECTION 12: Ecological information

12.1 Toxicity

Toxicity to fish: LC0 - Danio rerio (previous name: Brachydanio rerio) - 4 mg/L - 96 h.
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: EC0 - Pseudomonas putida - 125 mg/L - 30 min.

12.2 Persistence and degradability

The effects of dichlorine-substituted anilines on guelph loam were studied. Several dichloroanilines at concentrations of 5 to 100 ug/g soil was inhibitory against the oxidation of the nitrogen of ammonia to nitrite nitrogen, but not nitrite nitrogen to nitrate nitrogen. It showed almost a linear rate of decomposition over the 12 wk period of the experiment. The dichloroanilines were more persistent than aniline or the monochloroanilines. Dichloroanilines

12.3 Bioaccumulative potential

An estimated BCF of 76 was calculated for 2,3-dichloroaniline(SRC), using the log Kow of 2.78(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

12.4 Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2,3-dichloroaniline can be estimated to be about 120(SRC). According to a classification scheme(2), this Koc value suggests that 2,3-dichloroaniline is expected to have high mobility in soil(SRC). Aromatic amines such as various chloro- and dichloroaniline isomers, have been observed to undergo rapid and reversible covalent bonding with humic materials in aqueous solution; the initial bonding reaction is followed by a slower and much less reversible reaction believed to represent the addition of the amine to quinoidal structure followed by oxidation of the product to give an amino-substituted quinone; these processes represent pathways by which aromatic amines may be converted to latent forms in the biosphere(3).

12.5 Other adverse effects

no data available

SECTION 13: Disposal considerations

13.1 Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

14.1 UN Number

ADR/RID: UN3442 (For reference only, please check.)

IMDG: UN3442 (For reference only, please check.)

IATA: UN3442 (For reference only, please check.)

14.2 UN Proper Shipping Name

ADR/RID: DICHLOROANILINES, SOLID (For reference only, please check.)

IMDG: DICHLOROANILINES, SOLID (For reference only, please check.)

IATA: DICHLOROANILINES, SOLID (For reference only, please check.)

14.3 Transport hazard class(es)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

14.4 Packing group, if applicable

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

14.5 Environmental hazards

ADR/RID: Yes

IMDG: Yes

IATA: Yes

14.6 Special precautions for user

no data available

14.7 Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations specific for the product in question

Chemical name	Common names and synonyms	CAS number	EC number
2,3-dichloroaniline	2,3-dichloroaniline	608-27-5	210-157-9
European Inventory of Existing Commercial Chemical Substances (EINECS)			Listed.
EC Inventory			Listed.
United States Toxic Substances Control Act (TSCA) Inventory			Listed.
China Catalog of Hazardous chemicals 2015			Listed.
New Zealand Inventory of Chemicals (NZIoC)			Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS)			Listed.
Vietnam National Chemical Inventory			Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)			Listed.
Korea Existing Chemicals List (KECL)			Listed.

SECTION 16: Other information

Information on revision

Creation Date	July 15, 2019
Revision Date	July 15, 2019

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.

Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

2,3-Dichloroaniline is included in Amides category.