Glyphosate Safety Data Sheets

Serious eye damage, Category 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2

If inhaled

Following skin contact

Following eye contact

Following ingestion

SYMPTOMS: Symptoms of exposure to this compound include irritation of the skin, gastrointestinal tract and respiratory tract, convulsions and coma. It may also cause enhanced breathing. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, respiratory tract and gastrointestinal tract. When heated to decomposition it emits very toxic fumes of nitrogen oxides and phosphorus oxides. (NTP, 1992)

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Use water spray, powder, alcohol-resistant foam, carbon dioxide.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered plastic containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Sweep spilled substance into plastic containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment.

NO open flames, NO sparks and NO smoking. Prevent build-up of electrostatic charges (e.g., by grounding). Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed. Do NOT store or transport in containers made from galvanized steel or unlined steel. Store in an area without drain or sewer access.Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water.

Occupational Exposure limit values

Biological limit values

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on heating. This produces toxic fumes including nitrogen oxides and phosphorus oxides. Attacks iron and galvanized steel.

Negligible volatility

Dust explosion possible if in powder or granular form, mixed with air. If dry, it can be charged electrostatically by swirling, pneumatic transport, pouring, etc.GLYPHOSATE may react with galvanized steel or unlined steel (except stainless steel) containers to produce hydrogen gas which may form a highly combustible or explosive gas mixture. It can react with caustic (basic) materials to liberate heat. It is corrosive to iron. (NTP, 1992)

no data available

Incompatible materials: Strong oxidizing agents, metals, bases.

When heated to decomposition it emits very toxic fumes of /nitrogen and phosphorus oxides/.

Acute toxicity

• Oral: LD50 Goat oral 3530 mg/kg
• Inhalation: LC50 Rat inhalation >4.98 mg/L air/4 hr
• Dermal: LD50 Rabbit percutaneous >5000 mg/kg

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50; Species: /Oncorhynchus mykiss/ (Rainbow trout) weight 0.8 g; Conditions: static bioassay without aeration, 12 deg C, pH 7.2-7.5, water hardness 40-50 mg/L as calcium carbonate and alkalinity of 30-35 mg/L Concentration: 130 mg/L for 96 hr (95% confidence interval: 108-156 mg/L) /Technical material, 96.7%
• Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water Flea) age <24 hr; Conditions: freshwater, static; Concentration: >22000 ug/L for 48 hr; Effect: intoxication, immobilization /80% purity
• Toxicity to algae: EC50; Species: Microcystis aeruginosa (Blue-Green Algae) Exponential Growth Phase; Conditions: freshwater, static, 22 deg C; Concentration: 251400 ug/L for 21 days; Effect: decreased population growth rate /formulation
• Toxicity to microorganisms: no data available

AEROBIC: When glyphosate was incubated in Williams silt loam soil (pH 6.4, 1.9% organic matter), 19% degradation occurred in 9 days. No degradation was noted in sterilized soil(1). In shake-flask metabolism studies, glyphosate was rapidly and completely biodegraded in the presence of soil microorganisms under both aerobic and anaerobic conditions(2). After 28 days under aerobic conditions, 45-55% of the glyphosate was mineralized using Ray silt loam soil, Lintonia sandy loam soil, and Drummer silty clay loam soil. Norfolk sandy loam mineralized glyphosate at a much slower, but still significant, rate. In greenhouse experiments, the half-lives of glyphosate in Ray, Drummer and Norfolk soil was 3, 27, and 130 days, respectively(2). The biodegradation half-life of glyphosate in a Kickapoo sandy loam and Dupo silt loam soil were 1.85 and 2.06 days, respectively, under aerobic conditions. The major degradation product observed was aminomethyl phosphonic acid. The aerobic and anaerobic biodegradation half-life of glyphosate in a flooded silty clay loam sediment was 7 and 8.1 days, respectively(3).

In controlled laboratory studies using glyphosate at levels 3 to 4 times the recommended application rates, BCF values in fish tissue 10-14 days post application ranged from 0.2 to 0.3(1). A BCF value of 0.52 (whole body) was measured in bluegill (Lepomis macrochirus) exposed for 28 days(2). BCF values of 0.38 for edible tissues and 0.63 for non-edible tissues have been reported(3). According to a classification scheme(4), these BCF data suggest that bioconcentration in aquatic organisms is low(SRC).

When applied to clay loam or muck soil at an application rate of 56 kg/ha, glyphosate was rapidly inactivated. This inactivation was probably the result of reversible adsorption to clay and organic matter. Iron and aluminum clays and organic matter adsorbed more glyphosate than sodium and calcium clays and was readily bound to kaolinite, illite, bentonite, charcoal and muck but not to ethyl cellulose. (14)C-Labeled glyphosate was degraded in soil and (14)CO2 was released.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Other Information

Sodium, potassium and amine salts are readily soluble in water.Carrier solvents used in commercial formulations may change physical and toxicological properties.