Pyrene Safety Data Sheets
SAFETY DATA SHEETS
According to the UN GHS revision 8
SECTION 1: Identification
1.1 GHS Product identifier
| Product name | Pyrene |
|---|
1.2 Other means of identification
| Product number | - |
|---|---|
| Other names | Pyrene; Pyren; Benzo[def]phenanthrene |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses | Dyes |
|---|---|
| Uses advised against | no data available |
1.4 Supplier's details
| Company | Echemi.com |
|---|---|
| Address | Echemi.com |
| Telephone | Echemi.com |
1.5 Emergency phone number
| Emergency phone number | Echemi.com |
|---|---|
| Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Not classified.
2.2 GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
|---|---|
| Signal word | No signal word |
| Hazard statement(s) | none |
| Precautionary statement(s) | |
| Prevention | none |
| Response | none |
| Storage | none |
| Disposal | none |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Pyrene | Pyrene | 129-00-0 | 204-927-3 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Pyrene is a carcinogenic agent and is absorbed by the skin. It is a skin irritant, a suspected mutagen, and an equivocal tumor-causing agent. Workers exposed to 3 to 5 mg/m3 of pyrene exhibited some teratogenic effects. Pyrene is a polycyclic aromatic hydrocarbon (PAH). The acute toxicity of pure PAHs appears low when administered orally or dermally to rats or mice. Human exposure to PAHs is almost exclusively via the gastrointestinal and respiratory tracts, and approximately 99 percent is ingested in the diet. Despite the high concentrations of pyrene to which humans may be exposed through food, there is currently little information available to implicate diet-derived PAHs as the cause of serious health effects. (EPA, 1998)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aromatic hydrocarbons and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
This chemical is a combustible solid. Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers. Poisonous gases are produced in fire. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position.
5.2 Specific hazards arising from the chemical
When heated to decomposition, it emits acrid smoke and fumes. (EPA, 1998)
5.3 Special protective actions for fire-fighters
Use water spray, carbon dioxide, dry powder, alcohol-resistant foam, polymer foam.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder.
6.2 Environmental precautions
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder.
6.3 Methods and materials for containment and cleaning up
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames, NO sparks and NO smoking. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants. Keep in a well-ventilated room.Store in a cool, dry place.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
MAK skin absorption (H)
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety spectacles.
Skin protection
Protective gloves.
Respiratory protection
Avoid inhalation of dust.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Pyrene is a colorless solid, solid and solutions have a slight blue fluorescence. Used in biochemical research. (EPA, 1998) |
|---|---|
| Colour | Monoclinic prismatic tablets from alcohol or by sublimation; pure pyrene is colorless |
| Odour | no data available |
| Melting point/freezing point | 250°C(dec.)(lit.) |
| Boiling point or initial boiling point and boiling range | 404°C(lit.) |
| Flammability | Gives off irritating or toxic fumes (or gases) in a fire. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 0°C(lit.) |
| Auto-ignition temperature | no data available |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | no data available |
| Solubility | less than 1 mg/mL at 72° F (NTP, 1992) |
| Partition coefficient n-octanol/water | log Kow = 4.88 |
| Vapour pressure | 2.28E-06mmHg at 25°C |
| Density and/or relative density | 1.271 |
| Relative vapour density | no data available |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
80 mg/cu m; NIOSH considers coal tar pitch volatiles to be potential occupational carcinogens. Coal tar pitch volatiles
Decomposes on heating. This produces irritating fumes.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
PYRENE reacts with nitrogen oxides to form nitro derivatives. It also reacts with 70% nitric acid. (NTP, 1992)
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizers. Coal tar pitch volatiles
10.6 Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 2700 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
CLASSIFICATION: D; not classifiable as to human carcinogenicity. BASIS FOR CLASSIFICATION: Based on no human data and inadequate data from animal bioassays. HUMAN CARCINOGENICITY DATA: None. ANIMAL CARCINOGENICITY DATA: Inadequate. Based on former classification system
Reproductive toxicity
no data available
STOT-single exposure
Exposure to sun may enhance the irritating effect of this substance. This may result in chronic skin discoloration.
STOT-repeated exposure
no data available
Aspiration hazard
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Oncorhynchus mykiss (Rainbow trout, weight 3.17 g, length 6.2 cm); Conditions: freshwater, static, 11.0 deg C, pH 6.19; Concentration: >2000 ug/L for 24 hr /formulation
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, renewal; Concentration: 72.7 ug/L for 7 days; Effect: growth rate />99% purity
- Toxicity to algae: EC50; Species: Pseudokirchneriella subcapitata (Green algae, age <24 hr); Conditions: freshwater, static; Concentration: 894000 ug/L for 72 hr; Effect: increased intoxication, immobilization /98% purity
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
Polycyclic aromatic hydrocarbons with 4 or less aromatic rings are degraded by microbes and are readily metabolized by multicellular organisms; biodegradation may be the ultimate fate process. Polycyclic aromatic hydrocarbons
12.3 Bioaccumulative potential
Experimental BCF values of 72(1), 457(2), and 600-970(3) have been reported in rainbow trout, goldfish and fathead minnow respectively. According to a classification scheme(4), these BCF values suggest that bioconcentration in aquatic organisms is moderate to high(SRC). Pyrene was shown to bioaccumulate in worms exposed to contaminated sediment over a 4 week incubation period, reaching a maximum concn of 60.9 ng/g and an uptake rate constant of 0.0256 hr-L(5). Pyrene had biota-sediment accumulation factors of 0.76 and 0.92 in Elliptio complanata and Mya arenaria(6). BCFs for pyrene in the amphipod Diporeia spp were measured as 36,329, 30,671, 16,810 and 12,316 calculated from the time-weighted avg water concns of 34.0, 51.3, 84.5 and 130.7 ug/L, respectively(7).
12.4 Mobility in soil
Experimental Koc values determined with 5 sediment samples obtained from a freshwater lake in Louisiana were 64,954, 63,372, 73,127, 65,380 and 59,675(1). The Koc values of pyrene obtained with soil samples from Flint, MI and Bordone, Canada were 61,936 and 90,000 respectively(2). Measured Koc values of 160,000, 153,000, 98,700 and 169,000 were obtained for pyrene with suspended solids and sediment from the Boston Harbor, MA(3). An experimental Koc value of 76,000 was reported for pyrene with soil obtained from a water treatment facility in Sweden(4). Experimentally determined log Koc values between 4.9 and 5.4 were reported for pyrene with sediment obtained from Lake Michigan(5) and a log Koc value of 5.5 was reported with sediment obtained from the Boston Harbor, MA(6). Pyrene had a log Koc in sediment from Lake Ketelmeer, The Netherlands of 6.80 (3.75% organic carbon, 0-30 cm depth) and 5.95 (6.48% organic carbon, 40-120 cm depth)(7). Boston Harbor, MA sediment samples taken from South Dorchester Bay, North Quincy, Fort Point Channel and Spectacle Island had log Koc values of 3.54, 3.71, 4.32 and 4.55, respectively, in samples taken Dec 1999(9). According to a classification scheme(10), these Koc values suggest that pyrene is expected be immobile in soil.
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Pyrene | Pyrene | 129-00-0 | 204-927-3 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Not Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Pyrene is one of many polycyclic aromatic hydrocarbons - standards are usually established for them as mixtures, e.g., coal tar pitch volatiles.However, pyrene may be encountered as a laboratory chemical in its pure form.Health effects of exposure to the substance have not been investigated adequately.See ICSC 1415.
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.
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